Once 
Zorin v16.3 Lite installed by default has associate the 
windows executables with /Windows Apps/ application, which comes together with 
Playonlinux front end which uses 
Wine.
wineprefix = is a 
folder has inside the 
Virtual drive and it 
settings. Each
 Virtual drive contains the required /Windows/ files.
At first, Playonlinux has a default 
wineprefix (possible 64bit). User has to go to Configure > New > 
Create 32bit Virtual drive.
In the same dialog  -  Configure > Install 
components > install 
framework v4.5 (this will download also 1.1 / 2 / 3 / 3.5) possible some hard error(s) (MD5 CRC) will occur, but in the end is OK...
	
	
		
		
			When using Playonlinux, and you would like to test an application of you, when you double click the executable from linux explorer it runs it via Wine and Wine is not /sees/ the same wineprefix as Playonlinux...
		
		
	 
To run an executable on 
Playonlinux must
1. Put your exe into the virtual drive (optional)
2. Open playonlinux, click 
Configure, choose your drive in the left, choose 
Miscellaneous tab in the right
3. Click "
Run a .exe in this virtual drive", browse to your exe file, click Open
-->Your exe should run now
You can even create a shortcut for it:
1. Switch to 
General tab, click "Make a new 
shortcut from this virtual drive"
2. Playonlinux (aka Pol) will scan for executable files in your virtual drive which include your exe file as well (suppose you put it there earlier) or click 
browse
3. Choose your exe and create a shortcut for it
Once user has the Playonlinux shortcut can easily produce a 
desktop icon
Moreover when on 
Wine tab, there are some common functionalities such as
	
	
		
		
			but you know, goes a little bit slow compared to a win pc (also ~5 years ago tested plain Wine, was the same, slow). From dotnet6 and onwards MS releasing also linux distro, so the net apps, run natively on linux.
		
		
	 
source - 
https://www.playonlinux.com/en/topic-16997.html#m65891