Researchers made a new form of life with 6-letter DNA - these cells can make proteins that normal life can’t (April 2018)

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Every cell that's ever lived has been the result of the four-letter genetic alphabet: A, T, C and G -- the basic units of DNA. But now that's changed. In a visionary talk, synthetic biologist Floyd E. Romesberg introduces us to the first living organisms created with six-letter DNA -- the four natural letters plus two new man-made ones, X and Y -- and explores how this breakthrough could challenge our basic understanding of nature's design.

https://www.ted.com/talks/floyd_e_romesberg_the_radical_possibilities_of_man_made_dna
 
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