With increasing worldwide demand for safe blood, there is much interest in generating red blood cells in vitro as an alternative clinical product. However, available methods for in vitro generation of red cells from adult and cord blood progenitors do not yet provide a sustainable supply, and current systems using pluripotent stem cells as progenitors do not generate viable red cells. We have taken an alternative approach, immortalizing early adult erythroblasts generating a stable line, which provides a continuous supply of red cells.
https://www.nature.com/articles/ncomms14750
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https://www.nature.com/articles/ncomms14750
https://www.facebook.com/ScienceNaturePage/videos/1257912797674309/