Motor neurone disease
Motor neurone disease (MND) is a uncommon condition that affects the brain and nerves. It causes weakness that gets worse over time, more…
Amyotrophic Lateral Sclerosis (ALS)
In ALS, nerve cells in the brain and spinal cord that control movement stop functioning. The condition leads to paralysis, and patients eventually cannot breathe or swallow on their own. The disease afflicts about 350,000 people a year worldwide (25,000 ALS patients living in the USA), and about half of patients die within three years of diagnosis.
The company expects that if the stage three trial goes well, that the US Food and Drug Administration may give regulatory approval for mass use among doctors and patients. The trial will be measured by the ALSFR-S score responder analysis and final data is expected by 2019.
During the treatment process, doctors extract cells from the bone marrow of from patients with ALS, and the cells are multiplied and matured, then prepared for injection back into the patient. During the maturation process, the cells from the bone marrow are manipulated into behaving like brain cells, in that they produce materials that are the building blocks of the brain. When these modified cells are put back in patients, the building blocks circulate in the spinal fluid and help repair the damaged brain. (src)